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Article

PIK3CA-mutations in breast cancer.

Breast cancer research and treatment - 1 Dec 2022

Reinhardt Kristin, Stückrath Kathrin, Hartung Carolin, Kaufhold Sandy, Uleer Christoph, Hanf Volker, Lantzsch Tillmann, Peschel Susanne, John Jutta, Pöhler Marleen, Bauer Marcus, Bürrig Friedrich Karl, Weigert Edith, Buchmann Jörg, Kantelhardt Eva Johanna, Thomssen Christoph, Vetter Martina

Abstract excerpt

PURPOSE: Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to determine the prevalence of PIK3CA-mutations in a cohort of early stage breast cancer patients and the association to the course of disease. PATIENTS AND METHODS: From an unselected cohort of 1270 breast cancer patients (PiA, Prognostic Assessment in...

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Identifiers

PMID: 36279023
DOI: 10.1007/s10549-022-06637-w
PMCID: PMC9633529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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