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Article

Pattern of Somatic Mutations in the PIK3CA Oncogene and Their Role as a Potential Prognostic Biomarker in Breast Cancer Patients in Sri Lanka: A Pilot Study.

Asian Pacific journal of cancer prevention : APJCP - 1 Mar 2026

Cabraal Tharini Ruwinya, Kumarasinghe Iranthi, Perera Ranga, Balawardana Jayantha, Viswakula Sameera, Perera Nandika, Galhena Gayani Harendra

Abstract excerpt

BACKGROUND: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit-alpha (PIK3CA) oncogene is one of the most frequently mutated oncogenes in breast cancer, with mutations influencing prognosis and therapeutic response. This study aimed to determine the pattern of hotspot PIK3CA mutations and assess their association with clinicopathological parameters and relapse-free survival (RFS) among Sri Lankan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41793668
DOI: 10.31557/APJCP.2026.27.3.897

Genes

PIK3CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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