Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study.

doi:10.1371/journal.pone.0140293

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Article

Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study.

PloS one - 1 Jan 2015

Papaxoinis George, Kotoula Vassiliki, Alexopoulou Zoi, Kalogeras Konstantine T, Zagouri Flora, Timotheadou Eleni, Gogas Helen, Pentheroudakis George, Christodoulou Christos, Koutras Angelos, Bafaloukos Dimitrios, Aravantinos Gerasimos, Papakostas Pavlos, Charalambous Elpida, Papadopoulou Kyriaki, Varthalitis Ioannis, Efstratiou Ioannis, Zaramboukas Thomas, Patsea Helen, Scopa Chrisoula D, Skondra Maria, Kosmidis Paris, Pectasides Dimitrios, Fountzilas George

Abstract excerpt

BACKGROUND: The PI3K-AKT pathway is frequently activated in breast cancer. PIK3CA mutations are most frequently found in the helical (exon 9) and kinase (exon 20) domains of this protein. The aim of the present study was to examine the role of different types of PIK3CA mutations in combination with molecular biomarkers related to PI3K-AKT signaling in patients with early breast cancer. METHODS: Tumor tissue...

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PMID: 26452060
DOI: 10.1371/journal.pone.0140293
PMCID: PMC4599795

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