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Article

PIK3CA mutations in endocrine-resistant breast cancer.

Scientific reports - 31 May 2024

Schagerholm Caroline, Robertson Stephanie, Toosi Hosein, Sifakis Emmanouil G, Hartman Johan

Abstract excerpt

Around 75% of breast cancer (BC) patients have tumors expressing the predictive biomarker estrogen receptor α (ER) and are offered endocrine therapy. One-third eventually develop endocrine resistance, a majority with retained ER expression. Mutations in the phosphatidylinositol bisphosphate 3-kinase (PI3K) catalytic subunit encoded by PIK3CA is a proposed resistance mechanism and a pharmacological target in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Drug Resistance, Neoplasm

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Share to Receptor, ErbB-2

Source

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Identifiers

PMID: 38822093
DOI: 10.1038/s41598-024-62664-1
PMCID: PMC11143214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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