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Shared Cancer Dataset Analysis Identifies and Predicts the Quantitative Effects of Pan-Cancer Somatic Driver Variants.

Cancer research - 4 Jan 2023

Landau Jakob, Tsaban Linoy, Yaacov Adar, Ben Cohen Gil, Rosenberg Shai

Abstract excerpt

Driver mutations endow tumors with selective advantages and produce an array of pathogenic effects. Determining the function of somatic variants is important for understanding cancer biology and identifying optimal therapies. Here, we compiled a shared dataset from several cancer genomic databases. Two measures were applied to 535 cancer genes based on observed and expected frequencies of driver variants as...

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PMID: 36264175
DOI: 10.1158/0008-5472.CAN-22-1038

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