Article
Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations.
Cancer research - 15 Aug 2009
Carter Hannah, Chen Sining, Isik Leyla, Tyekucheva Svitlana, Velculescu Victor E, Kinzler Kenneth W, Vogelstein Bert, Karchin Rachel
Abstract excerpt
Large-scale sequencing of cancer genomes has uncovered thousands of DNA alterations, but the functional relevance of the majority of these mutations to tumorigenesis is unknown. We have developed a computational method, called Cancer-specific High-throughput Annotation of Somatic Mutations (CHASM), to identify and prioritize those missense mutations most likely to generate functional changes that enhance tumor...
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