Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.

doi:10.1212/WNL.0000000000201439

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Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.

Neurology - 24 Jan 2023

Saracino Dario, Sellami Leila, Boniface Hugo, Houot Marion, Pélégrini-Issac Mélanie, Funkiewiez Aurélie, Rinaldi Daisy, Locatelli Maxime, Azuar Carole, Causse-Lemercier Valérie, Jaillard Alice, Pasquier Florence, Chastan Mathieu, Wallon David, Hitzel Anne, Pariente Jérémie, Pallardy Amandine, Boutoleau-Bretonnière Claire, Guedj Eric, Didic Mira, Migliaccio Raffaella, Kas Aurélie, Habert Marie-Odile, Le Ber Isabelle

Abstract excerpt

BACKGROUND AND OBJECTIVES: GRN variants are a frequent cause of familial frontotemporal dementia (FTD). Monitoring disease progression in asymptomatic carriers of genetic variants is a major challenge in delivering preventative therapies before clinical onset. This study aimed to assess the usefulness of fluorodeoxyglucose (FDG)-PET in identifying metabolic changes in presymptomatic GRN carriers (PS-GRN+) and to...

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PMID: 36257714
DOI: 10.1212/WNL.0000000000201439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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