Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers.

doi:10.1212/WNL.0b013e3182a8237e

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Article

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers.

Neurology - 8 Oct 2013

Jacova Claudia, Hsiung Ging-Yuek R, Tawankanjanachot Itthipol, Dinelle Katie, McCormick Siobhan, Gonzalez Marjorie, Lee Hyunsoo, Sengdy Pheth, Bouchard-Kerr Phoenix, Baker Matthew, Rademakers Rosa, Sossi Vesna, Stoessl A Jon, Feldman Howard H, Mackenzie Ian R

Abstract excerpt

OBJECTIVE: In this prospective cohort study, we investigated cerebral glucose metabolism reductions on [(18)F]-fluorodeoxyglucose (FDG)-PET in progranulin (GRN) mutation carriers prior to frontotemporal dementia (FTD) onset. METHODS: Nine mutation carriers (age 51.5 ± 13.5 years) and 11 noncarriers (age 52.7 ± 9.5 years) from 5 families with FTD due to GRN mutations underwent brain scanning with FDG-PET and MRI...

Topics

Adult
Aged
Brain Mapping
Dementia
Disease Progression
Female
Fluorodeoxyglucose F18
Frontal Lobe
Glucose
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

Magnetic Resonance Imaging

Male

Middle Aged

Mutation

Positron-Emission Tomography

Progranulins

Retrospective Studies

Source

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Identifiers

PMID: 24005336
DOI: 10.1212/WNL.0b013e3182a8237e
PMCID: PMC3806924

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