Article
White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study.
NeuroImage. Clinical - 1 Jan 2019
Sudre Carole H, Bocchetta Martina, Heller Carolin, Convery Rhian, Neason Mollie, Moore Katrina M, Cash David M, Thomas David L, Woollacott Ione O C, Foiani Martha, Heslegrave Amanda, Shafei Rachelle, Greaves Caroline, van Swieten John, Moreno Fermin, Sanchez-Valle Raquel, Borroni Barbara, Laforce Robert, Masellis Mario, Tartaglia Maria Carmela, Graff Caroline, Galimberti Daniela, Rowe James B, Finger Elizabeth, Synofzik Matthis, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Santana Isabel, Ducharme Simon, Butler Chris, Gerhard Alex, Levin Johannes, Danek Adrian, Frisoni Giovanni B, Sorbi Sandro, Otto Markus, Zetterberg Henrik, Ourselin Sebastien, Cardoso M Jorge, Rohrer Jonathan D
Abstract excerpt
Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative disorders with both sporadic and genetic forms. Mutations in the progranulin gene (GRN) are a common cause of genetic FTD, causing either a behavioural presentation or, less commonly, language impairment. Presence on T2-weighted images of white matter hyperintensities (WMH) has been previously shown to be more commonly associated with GRN...
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