Article
Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementia C9orf72 and GRN mutation carriers.
Journal of Alzheimer's disease : JAD - 1 Aug 2025
Lee Hyunwoo, Chatterjee Atri, Mackenzie Ian Ra, Scott Imogene, Beg Mirza Faisal, Popuri Karteek, Wittenberg Dana, Rademakers Rosa, Hsiung Ging-Yuek Robin
Abstract excerpt
BackgroundNeuropsychiatric symptoms (NPS) progress differently among individuals with autosomal dominant familial frontotemporal dementia (FTD) caused by genetic mutations in granulin (GRN+) or chromosome 9 open reading frame 72 (C9orf72+).ObjectiveTo determine whether these differences begin prior to the onset of dementia, we compared the longitudinal rates of change of NPS among C9orf72+, GRN+, and noncarrier...
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