Article
Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia.
Neurology - 12 Dec 2022
Poos Jackie M, Grandpierre Leonie D M, van der Ende Emma L, Panman Jessica L, Papma Janne M, Seelaar Harro, van den Berg Esther, van 't Klooster Ronald, Bron Esther, Steketee Rebecca, Vernooij Meike W, Pijnenburg Yolande A L, Rombouts Serge A R B, van Swieten John, Jiskoot Lize C
Abstract excerpt
BACKGROUND AND OBJECTIVES: It is important to identify at what age brain atrophy rates in genetic frontotemporal dementia (FTD) start to accelerate and deviate from normal aging effects to find the optimal starting point for treatment. We investigated longitudinal brain atrophy rates in the presymptomatic stage of genetic FTD using normative brain volumetry software. METHODS: Presymptomatic GRN, MAPT, and C9orf72...
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