Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers.

NeuroImage. Clinical - 1 Jan 2018

Olm Christopher A, McMillan Corey T, Irwin David J, Van Deerlin Vivianna M, Cook Philip A, Gee James C, Grossman Murray

Abstract excerpt

Introduction: Mutations in the progranulin (GRN) gene are a major source of inherited frontotemporal degeneration (FTD) spectrum disorders associated with TDP-43 proteinopathy. We use structural MRI to identify regions of baseline differences and longitudinal changes in gray matter (GM) and white matter (WM) in presymptomatic GRN mutation carriers (pGRN+) compared to young controls (yCTL). Methods: Cognitively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anisotropy
Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diffusion Magnetic Resonance Imaging

Share to Diffusion Tensor Imaging

Share to Gray Matter

Share to Magnetic Resonance Imaging

Share to Progranulins

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 29984158
DOI: 10.1016/j.nicl.2018.05.017
PMCID: PMC6029561

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers.PMID 29984158Read ↗

Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI studySemantic proximity Read ↗

White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study.Semantic proximity Read ↗

Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.Semantic proximity Read ↗

Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers.Semantic proximity Read ↗

Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.Semantic proximity Read ↗

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.Semantic proximity Read ↗

Presymptomatic studies in genetic frontotemporal dementiaSemantic proximity Read ↗

Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study.Semantic proximity Read ↗

Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementia C9orf72 and GRN mutation carriers.Semantic proximity Read ↗

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia.Semantic proximity Read ↗

Extensive White Matter Involvement in Patients With Frontotemporal Lobar DegenerationSemantic proximity Read ↗

Composite grey matter fingerprints for genetic frontotemporal dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.