Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?

doi:10.3233/JAD-150270

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Article

Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease?

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Caroppo Paola, Habert Marie-Odile, Durrleman Stanley, Funkiewiez Aurélie, Perlbarg Vincent, Hahn Valérie, Bertin Hugo, Gaubert Malo, Routier Alexandre, Hannequin Didier, Deramecourt Vincent, Pasquier Florence, Rivaud-Pechoux Sophie, Vercelletto Martine, Edouart Geoffrey, Valabregue Romain, Lejeune Pascal, Didic Mira, Corvol Jean-Christophe, Benali Habib, Lehericy Stephane, Dubois Bruno, Colliot Olivier, Brice Alexis, Le Ber Isabelle

Abstract excerpt

The preclinical stage of frontotemporal lobar degeneration (FTLD) is not well characterized. We conducted a brain metabolism (FDG-PET) and structural (cortical thickness) study to detect early changes in asymptomatic GRN mutation carriers (aGRN+) that were evaluated longitudinally over a 20-month period. At baseline, a left lateral temporal lobe hypometabolism was present in aGRN+ without any structural changes....

Topics

Adult
Asymptomatic Diseases
Disease Progression
Female
Fluorodeoxyglucose F18
Frontal Lobe
Frontotemporal Lobar Degeneration
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

Longitudinal Studies

Magnetic Resonance Imaging

Male

Mutation

Organ Size

Positron-Emission Tomography

Progranulins

Radiopharmaceuticals

Temporal Lobe

Source

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Identifiers

PMID: 26401709
DOI: 10.3233/JAD-150270
PMCID: PMC4923734

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