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Article

Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy.

Clinical laboratory - 1 Oct 2022

Song Cangsang, Li Xingde, Zhang Hanshu, Bao Jinying, Lu Wei, Peng Qingping, Zhang Yang

Abstract excerpt

BACKGROUND: This study aimed to identify the effects of multidrug resistance gene 1 (MDR1) and UGT gene polymorphisms on the plasma concentration of VPA in subjects with epilepsy and provide a reference for individualized medicine of patients with epilepsy. METHODS: One hundred subjects with epilepsy who were treated with sustained release VPA monotherapy were enrolled. Sanger sequencing was used to detect the...

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Source

Identifiers

PMID: 36250837
DOI: 10.7754/Clin.Lab.2022.220101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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