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Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients.

Pharmacogenomics - 1 Feb 2023

Zheng Xiao-Xiao, You Yu-Xin, Zhao Lin-Lin, Du Yan, Xu Sheng-Qiu, Tang Dao-Quan

Abstract excerpt

Aim: To evaluate the association between genetic polymorphisms and plasma concentration-to-dose ratio of valproic acid (CDRV) in Chinese epileptic patients. Methods: A total of 46 epileptic patients treated with valproic acid therapy were enrolled. 18 SNPs in nine genes related to valproic acid were directly sequenced with Sanger methods. Results: Patients carrying UGT1A6 heterozygous genotypes had significantly...

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Identifiers

PMID: 36718958
DOI: 10.2217/pgs-2022-0156

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