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Article

Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.

European journal of clinical pharmacology - 1 Apr 2018

Wang Ping, Lin Xiao-Qian, Cai Wen-Ke, Xu Gui-Li, Zhou Meng-Di, Yang Mei, He Gong-Hao

Abstract excerpt

PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Recently, increasing evidence suggested that polymorphisms in UGT2B7 gene were associated with VPA pharmacokinetics, but results remained controversial. Therefore, a meta-analysis was performed to derive a more precise evaluation between C802T, C161T, and G211T polymorphisms and plasma concentration of VPA. METHODS: The PubMed,...

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PMID: 29243113
DOI: 10.1007/s00228-017-2395-z

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