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Article

Effect of UGT1A6 and UGT2B7 polymorphisms on the valproic acid serum concentration and drug-induced liver injury.

Pharmacogenomics - 1 Jan 2024

Yu Mengchen, Zhao Yan, Zhou Fan, Li Weiliang, Liu Jing, Zhao Linlin, Song Zhirui, Tong Ling, Zhang Ying, Wang Yajuan, Shang Shenglan, Yu Airong

Abstract excerpt

Aim: Valproic acid (VPA) is a classic broad-spectrum antiepileptic drug, with significant pharmacokinetic variability. Genetic polymorphisms contribute to this variability, influencing both VPA trough serum concentration (VPA concentration) and VPA-induced liver injury. Our study aims to investigate the association between polymorphisms of uridine diphosphate glucuronyl transferase (UGT) 1A6, UGT2B7 and VPA...

Read the complete abstract on PubMed

Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 39564784
DOI: 10.1080/14622416.2024.2409061

Genes

UGT1A6
UGT2B7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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