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Article

Effect of UGT2B7 genetic variants on serum valproic acid concentration.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Aug 2013

Ma Hongying, Zhang Ting, Gong Zhicheng, Zhou Boting, Zou Ming, Xiao Shan, Zhu Wu

Abstract excerpt

OBJECTIVE: To investigate the effect of UGT2B7 A268G and UGT2B7 G211T genetic polymorphism on serum drug concentration of valproic acid (VPA). METHODS: Genetic polymorphisms of UGT2B7 A268G and UGT2B7 G211T were tested in 248 epileptic patients by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Data including basic information, epilepsy type, times and doses of drug, treatment...

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Identifiers

PMID: 23981985
DOI: 10.3969/j.issn.1672-7347.2013.08.002

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