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Article

Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2021

Du Zhaosong, Xu Hua, Zhao Peiwei, Wang Jing, Xu Qiong, Liu Maochang

Abstract excerpt

We explored the potential effects of genetic variations on the concentration to dose ratio (CDR) of valproic acid (VPA) in paediatric epilepsy patients.Two hundred and twenty-nine epileptic children on VPA monotherapy were included, and the VPA trough concentrations at steady-state of all subjects were determined.Nineteen single nucleotide polymorphisms (SNPs) of seven selected genes related to the metabolising...

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Source

Identifiers

PMID: 34000957
DOI: 10.1080/00498254.2021.1931554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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