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Article

Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy.

Seizure - 1 Oct 2017

Mei Shenghui, Feng Weixing, Zhu Leting, Yu Yazhen, Yang Weili, Gao Baoqin, Wu Xiaojuan, Zhao Zhigang, Fang Fang

Abstract excerpt

PURPOSE: The aim of the study is to evaluate the association between genetic polymorphisms and valproic acid (VPA) concentration to dose ratio in children with epilepsy on VPA monotherapy. METHODS: A total of 137 children, aged 3.5-18 years, (89 males and 48 females) with epilepsy on sustained-release VPA monotherapy were enrolled. Trough plasma concentrations of VPA at steady-state were measured using an AXSYM...

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Source

Identifiers

PMID: 28763744
DOI: 10.1016/j.seizure.2017.07.005

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