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Article

Prevalence of UGT1A6 polymorphisms in children with epilepsy on valproate monotherapy.

Neurology India - 1 Jan 2000

Jain Puneet, Shastri Shivaram, Gulati Sheffali, Kaleekal Thomas, Kabra Madhulika, Gupta Neerja, Gupta Y K, Pandey Ravindra Mohan

Abstract excerpt

BACKGROUND: Valproate is a commonly used anticonvulsant drug. Uridine 5΄-diphospho (UDP)-glucuronosyltransferase (UGT) contributes to around 50% of valproate metabolism and its polymorphisms may be important for explaining the considerable variation in valproate levels in patients with epilepsy. AIM: This study was aimed to analyze the genetic polymorphisms of UGT1A6 in Indian children with epilepsy and their...

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Identifiers

PMID: 25751467
DOI: 10.4103/0028-3886.152631

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