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Article

Effect of CYP2C19, UGT1A8, and UGT2B7 on valproic acid clearance in children with epilepsy: a population pharmacokinetic model.

European journal of clinical pharmacology - 1 Aug 2018

Mei Shenghui, Feng Weixing, Zhu Leting, Li Xingang, Yu Yazhen, Yang Weili, Gao Baoqin, Wu Xiaojuan, Fang Fang, Zhao Zhigang

Abstract excerpt

PURPOSE: Valproic acid (VPA) is an important drug in seizure control with great inter-individual differences in metabolism and treatment effect. This study aims to identify the effects of genetic variants on VPA clearance in a population pharmacokinetic (popPK) model in children with epilepsy. METHODS: A total of 325 VPA plasma concentrations from 290 children with epilepsy were used to develop the popPK model by...

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Anticonvulsants
Child
Cytochrome P-450 CYP2C19
Epilepsy
Glucuronosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Clearance Rate

Models, Biological

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PMID: 29666902
DOI: 10.1007/s00228-018-2440-6

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