Article
Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer.
International journal of cancer - 20 Aug 2002
Verhage Bas A J, van Houwelingen Kjeld, Ruijter T Emiel G, Kiemeney Lambertus A, Schalken Jack A
Abstract excerpt
E-cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at -160 bp relative to the transcription-start site of the E-cadherin gene promoter. Eighty-two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A-allele...
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