Article
A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy.
RNA biology - 15 Oct 2021
Martens Leonie, Rühle Frank, Witten Anika, Meder Benjamin, Katus Hugo A, Arbustini Eloisa, Hasenfuß Gerd, Sinner Moritz F, Kääb Stefan, Pankuweit Sabine, Angermann Christiane, Bornberg-Bauer Erich, Stoll Monika
Abstract excerpt
lncRNAs are at the core of many regulatory processes and have also been recognized to be involved in various complex diseases. They affect gene regulation through direct interactions with RNA, DNA or proteins. Accordingly, lncRNA structure is likely to be essential for their regulatory function. Point mutations, which manifest as SNPs (single nucleotide polymorphisms) in genome screens, can substantially alter...
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