Article
Exploring the molecular basis of RNA recognition by the dimeric RNA-binding protein via molecular simulation methods.
RNA biology - 1 Nov 2016
Chang Shan, Zhang Da-Wei, Xu Lei, Wan Hua, Hou Ting-Jun, Kong Ren
Abstract excerpt
RNA-binding protein with multiple splicing (RBPMS) is critical for axon guidance, smooth muscle plasticity, and regulation of cancer cell proliferation and migration. Recently, different states of the RNA-recognition motif (RRM) of RBPMS, one in its free form and another in complex with CAC-containing RNA, were determined by X-ray crystallography. In this article, the free RRM domain, its wild type complex and 2...
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