Article

A genetic variant alters the secondary structure of the lncRNA H19 and is associated with Dilated Cardiomyopathy

2021-01-23

Abstract excerpt

lncRNAs are at the core of many regulatory processes and have also been recognized to be involved in various complex diseases. They affect gene regulation through direct interactions with RNA, DNA or proteins. Accordingly, lncRNAs structure is likely to be essential for their regulatory function. Point mutations, which manifest as SNPs (single nucleotide polymorphisms) in genome screens, can substantially alter th...

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Literature Corpus work: d1386dc7-4da8-5434-9559-67a63a9519b2
DOI: 10.1101/2021.01.22.427739

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