Article
Somatic Mutational Landscape in Mexican Patients: CDH1 Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma.
International journal of molecular sciences - 21 Sept 2022
Cerrato-Izaguirre Dennis, Chirino Yolanda I, Prada Diddier, Quezada-Maldonado Ericka Marel, Herrera Luis A, Hernández-Guerrero Angélica, Alonso-Larraga Juan Octavio, Herrera-Goepfert Roberto, Oñate-Ocaña Luis F, Cantú-de-León David, Meneses-García Abelardo, Basurto-Lozada Patricia, Robles-Espinoza Carla Daniela, Camacho Javier, García-Cuellar Claudia M, Sánchez-Pérez Yesennia
Abstract excerpt
The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to present the mutational landscape of GA from 50 Mexican patients who were treated at The Instituto Nacional de...
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