Article
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer.
Familial cancer - 1 Jun 2015
Donner Iikki, Kiviluoto Tuula, Ristimäki Ari, Aaltonen Lauri A, Vahteristo Pia
Abstract excerpt
Gastric cancer is the fourth most common cancer worldwide and the second leading cause of cancer mortality. Three hereditary gastric cancer syndromes have been described; hereditary diffuse gastric cancer (HDGC), familial intestinal gastric cancer (FIGC) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Thirty per cent of HDGC families have heterozygous germline mutations in CDH1, which...
Topics
- Antigens, CD
- Cadherins
- Exome
- F-Box Proteins
- Female
- Genetic Predisposition to Disease
- Histone-Lysine N-Methyltransferase
- Humans
- Loss of Heterozygosity
- Male
- Methyltransferases