Article
CDH1 mutations recurrence and global clustering in genetically tested families with hereditary diffuse gastric cancer syndrome: results from a systematic study.
Familial cancer - 1 Apr 2023
Corso Giovanni, Tagliaferri Valentina, Massari Giulia, Cioffi Antonio, Rossi Elisabetta Maria Cristina, Veronesi Paolo, Magnoni Francesca
Abstract excerpt
The global distribution of germline CDH1 mutations in hereditary diffuse gastric cancer families, is highly heterogenous. The aim of this study was to determine if there is any geographic clustering of CDH1 mutations in families with the hereditary diffuse gastric cancer syndrome. Data from 1998...
Topics
- Humans
- Stomach Neoplasms
- Genetic Predisposition to Disease
- Pedigree
- Mutation
- Cadherins
- Germ-Line Mutation
- Adenocarcinoma
- Antigens, CD