Article
Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.
JAMA network open - 1 Dec 2022
Liu Ze-Xian, Zhang Xiao-Long, Zhao Qi, Chen Yungchang, Sheng Hui, He Cai-Yun, Sun Yu-Ting, Lai Ming-Yu, Wu Min-Qing, Zuo Zhi-Xiang, Wang Wei, Zhou Zhi-Wei, Wang Feng-Hua, Li Yu-Hong, Xu Rui-Hua, Qiu Miao-Zhen
Abstract excerpt
Importance: The E-cadherin gene, CDH1, and the α-E-catenin gene, CTNNA1, were previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes, explaining 25% to 50% of HDGC cases. The genetic basis underlying disease susceptibility in the remaining 50% to 75% of patients wi...
Topics
- Adult
- Female
- Humans
- Male
- Adenocarcinoma
- Adenosine Triphosphatases
- Cohort Studies
- East Asian People
- Exome Sequencing
- Genetic Predisposition to Disease
- MicroRNAs
- Pedigree
- Retrospective Studies
- RNA-Binding Proteins