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Article

Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.

Cancer research - 1 Apr 2016

Li Xiangchun, Wu William K K, Xing Rui, Wong Sunny H, Liu Yuexin, Fang Xiaodong, Zhang Yanlin, Wang Mengyao, Wang Jiaqian, Li Lin, Zhou Yong, Tang Senwei, Peng Shaoliang, Qiu Kunlong, Chen Longyun, Chen Kexin, Yang Huanming, Zhang Wei, Chan Matthew T V, Lu Youyong, Sung Joseph J Y, Yu Jun

Abstract excerpt

Gastric cancer is not a single disease, and its subtype classification is still evolving. Next-generation sequencing studies have identified novel genetic drivers of gastric cancer, but their use as molecular classifiers or prognostic markers of disease outcome has yet to be established. In this study, we integrated somatic mutational profiles and clinicopathologic information from 544 gastric cancer patients...

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Identifiers

PMID: 26857262
DOI: 10.1158/0008-5472.CAN-15-2443

Genes

AKAP6
CDH1
CNBD1
ITGAV
NBEA

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