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Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline CDH1 Variants.

Cancer research - 1 Jun 2020

Wang Sam C, Yeu Yunku, Hammer Suntrea T G, Xiao Shu, Zhu Min, Hong Changjin, Clemenceau Jean R, Yoon Lynn Y, Nassour Ibrahim, Shen Jeanne, Agarwal Deepak, Reznik Scott I, Mansour John C, Yopp Adam C, Zhu Hao, Hwang Tae Hyun, Porembka Matthew R

Abstract excerpt

Hispanic/Latino patients have a higher incidence of gastric cancer and worse cancer-related outcomes compared with patients of other backgrounds. Whether there is a molecular basis for these disparities is unknown, as very few Hispanic/Latino patients have been included in previous studies. To determine the genomic landscape of gastric cancer in Hispanic/Latino patients, we performed whole-exome sequencing (WES)...

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Identifiers

PMID: 32269045
DOI: 10.1158/0008-5472.CAN-19-2918
PMCID: PMC7489496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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