Article
Identification of a rapid mammalian deadenylation-dependent decay pathway and its inhibition by a viral RNA element.
Molecular cell - 28 Dec 2006
Conrad Nicholas K, Mili Stavroula, Marshall Eleanor L, Shu Mei-Di, Steitz Joan A
Abstract excerpt
Cellular RNAs are subject to quality-control pathways that insure the fidelity of gene expression. We previously identified a 79 nt element, the ENE, that is essential for the nuclear accumulation of a viral polyadenylated nuclear (PAN) RNA. Here, we show that intron-less polyadenylated transcripts such as PAN RNA and beta-globin cRNA exhibit two-component exponential decay kinetics in which some transcripts are...
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