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Roles of Chromatin Remodelling and Molecular Heterogeneity in Therapy Resistance in Glioblastoma

9 Oct 2022

Abstract excerpt

Cancer stem cells (CSCs) represent a therapy-resistant reservoir in glioblastoma (GBM). It is now becoming clear that epigenetic and chromatin remodelling programs link the stemlike behaviour of CSCs to their treatment resistance. New evidence indicates that the epigenome of GBM cells is shaped by intrinsic and extrinsic factors, including their genetic makeup, their interactions and communication with other...

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Share to Epigenetics and DNA Methylation
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PMID: 36230865
DOI: 10.3390/cancers14194942

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