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Epigenetic Alterations in Glioblastoma Multiforme as Novel Therapeutic Targets: A Scoping Review

12 Jun 2025

Abstract excerpt

Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor with a dismal prognosis despite advances in multimodal treatment. Conventional therapies fail to achieve durable responses due to GBM's molecular heterogeneity and capacity to evade therapeutic pressures. Epigenetic alterations have emerged as critical contributors to GBM pathobiology, including aberrant DNA methylation, histone...

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PMID: 40565099
DOI: 10.3390/ijms26125634

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