Article

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets

2024-02-28

Abstract excerpt

Analysis of chromatin remodelling in neoplastic stem cells as compared to ontogenetically related neural stem cells, reveals multifactorial epigenetic regulation of signalling pathways known to contribute to glioblastoma development. It also identifies novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2 which could be further developed for future translation...

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Literature Corpus work: 220c3f3d-08c2-54ea-a276-fce5af97cb8a
DOI: 10.1101/2024.02.24.581853

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