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Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review

1 Jan 2020

Abstract excerpt

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 months. Current standard-of-care for GBM consists of gross total surgical resection followed by radiation with concurrent and adjuvant chemotherapy. Temozolomide (TMZ) is the first-choice chemotherapeutic agent in GBM; however, the development of resistance to TMZ often...

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PMID: 34337348
DOI: 10.20517/cdr.2020.79

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