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Article

Molecular mechanisms of temozolomide resistance in glioblastoma multiforme

1 May 2012

Abstract excerpt

Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing to its inherently profound resistance towards current standards of therapy. Considerable effort is being devoted to identifying the molecular basis of temozolomide resistance in GBMs and exploring novel therapeutic regimens that may improve overall survival. Several independent DNA repair mechanisms that normally safeguard...

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PMID: 22594898
DOI: 10.1586/era.12.37

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