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Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

12 Oct 2022

Abstract excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the portal region. Conversely, differential gene and protein expression is first detected in the central region. To further investigate cell-specific and spatially resolved dose-dependent changes in gene expression elicited by TCDD, single-nuclei RNA...

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PMID: 36222588
DOI: 10.1093/toxsci/kfac109

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