Article

TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule

2023-01-08

Abstract excerpt

The persistent environmental aryl hydrocarbon receptor agonist and hepatotoxin TCDD (2,3,7,8-tetrachlorodibenzo- p -dioxin) induces hepatic lipid accumulation (steatosis), inflammation (steatohepatitis) and fibrosis. Thousands of liver-expressed, nuclear-localized lncRNAs with regulatory potential have been identified; however, their roles in TCDD-induced hepatoxicity and liver disease are unknown. We analyzed si...

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Identifiers and source

Literature Corpus work: d857f055-57c2-5ede-ac0f-315050138e89
DOI: 10.1101/2023.01.07.523119

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