Article
Swimming exercise is a promising early intervention for autism-like behavior in Shank3 deletion rats.
CNS neuroscience & therapeutics - 1 Jan 2023
Xu Dan, Meng Yunchen, An Shasha, Meng Wenshu, Li Hanran, Zhang Weinan, Xue Yaqi, Lan Xinyu, Wang Xiaoxi, Li Mingjuan, Zhang Xiaoyan, Zhihao Zhang, Zhao Yu, Yang Haodong, Zhang Chen, Zhang Rong, Zhen Zhiping
Abstract excerpt
INTRODUCTION: SHANK3 is an important excitatory postsynaptic scaffold protein, and its mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum disorders (ASD), Philan McDermid syndrome (PMS), and intellectual disability (ID). Early prevention and treatment are important for Shank3 gene mutation disease. Swimming has been proven to have a positive effect on neurodegenerative...
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