Article

Prioritized RNA modification enzymes as risk genes for bipolar I disorder and schizophrenia

2026-01-27

Abstract excerpt

Enzyme-mediated RNA modifications provide a versatile and dynamic regulatory layer in brain development and neural function, orchestrated by over 100 RNA modification proteins (RMPs). A systematic assessment of contribution by common genetic variants in RMP genes to psychiatric disorders has been lacking. Here we curated 123 human RMPs—corresponding to 31 modification types on 6 RNA biotypes—and tested their genet...

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Literature Corpus work: 18428c1e-5567-52b9-8ef4-e0772cf96328
DOI: 10.64898/2026.01.26.26344826

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