Article
Expression quantitative trait loci (eQTLs) in microRNA genes are enriched for schizophrenia and bipolar disorder association signals.
Psychological medicine - 1 Jan 2015
Williamson V S, Mamdani M, McMichael G O, Kim A H, Lee D, Bacanu S, Vladimirov V I
Abstract excerpt
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) have substantial negative impact on the quality of human life. Both, microRNA (miRNA) expression profiling in SZ and BD postmortem brains [and genome-wide association studies (GWAS)] have implicated miRNAs in disease etiology. Here, we aim to determine whether significant GWAS signals observed in the Psychiatric Genetic Consortium (PGC) are enriched for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.