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Article

Cell-free mitochondrial DNA deletions in idiopathic, but not LRRK2, Parkinson's disease.

Neurobiology of disease - 1 Nov 2022

Puigròs Margalida, Calderon Anna, Pérez-Soriano Alexandra, de Dios Cristina, Fernández Manel, Colell Anna, Martí Maria-José, Tolosa Eduardo, Trullas Ramon

Abstract excerpt

Mitochondrial dysfunction happens in both idiopathic (iPD) and LRRK2-related Parkinson's disease (LRRK2-PD). Nonetheless, previous studies suggested that a different type of mitochondrial pathology underlies the neurodegeneration in these two disorders. To further explore this hypothesis, we developed a novel multiplex digital PCR assay that allows the absolute quantification of cell-free mitochondrial DNA...

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Source

Identifiers

PMID: 36208866
DOI: 10.1016/j.nbd.2022.105885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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