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Mitochondrial DNA homeostasis impairment and dopaminergic dysfunction: A trembling balance.

Ageing research reviews - 1 Apr 2022

Manini Arianna, Abati Elena, Comi Giacomo Pietro, Corti Stefania, Ronchi Dario

Abstract excerpt

Maintenance of mitochondrial DNA (mtDNA) homeostasis includes a variety of processes, such as mtDNA replication, repair, and nucleotides synthesis, aimed at preserving the structural and functional integrity of mtDNA molecules. Mutations in several nuclear genes (i.e., POLG, POLG2, TWNK, OPA1, DGUOK, MPV17, TYMP) impair mtDNA maintenance, leading to clinical syndromes characterized by mtDNA depletion and/or...

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PMID: 35114397
DOI: 10.1016/j.arr.2022.101578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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