Mitochondrial DNA Deletions Discriminate Affected from Unaffected LRRK2 Mutation Carriers

Abstract excerpt

In a recently published article in the Annals of Neurology, Bakshi and colleagues determined the concentration of the antioxidant urate in serum samples from ~1,500 individuals with or without LRRK2 mutations that were affected or unaffected by Parkinson disease (PD).1 In 3 independent cohorts, they detected significantly lower levels of urate in manifesting (LRRK2+/PD+) compared to nonmanifesting (LRRK2+/PD−)...

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