Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial Mechanisms of LRRK2 G2019S Penetrance

25 Aug 2020

Abstract excerpt

Several mutations in Leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson’s disease (PD). The most common substitution, G2019S, interferes with LRRK2 kinase activity, which is regulated by autophosphorylation. Yet, the penetrance of this gain-of-function mutation is incomplete, and thus far, few factors have been correlated with disease status in carriers. This includes (i) LRRK2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32982917
DOI: 10.3389/fneur.2020.00881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial Mechanisms of LRRK2 G2019S PenetrancePMID 32982917Read ↗

Mitochondrial DNA Deletions Discriminate Affected from Unaffected LRRK2 Mutation CarriersSemantic proximity Read ↗

LRRK2 and mitochondria: Recent advances and current views.Semantic proximity Read ↗

Molecular mechanisms defining penetrance of<i>LRRK2</i>-associated Parkinson’s diseaseSemantic proximity Read ↗

LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2 G2019S carriers and in vivoSemantic proximity Read ↗

Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in NeurodegenerationSemantic proximity Read ↗

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.Semantic proximity Read ↗

LRRK2 at the Crossroad of Aging and Parkinson's Disease.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2): balancing cellular homeostasis and Parkinson's disease (PD) pathogenesis.Semantic proximity Read ↗

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.Semantic proximity Read ↗

Cellular processes associated with LRRK2 function and dysfunction.Semantic proximity Read ↗

Identification & characterization of leucine-rich repeat kinase 2 & parkin RBR E3 ubiquitin protein ligase variants in patients with Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.