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Mitochondrial DNA Depletion in Respiratory Chain–Deficient P arkinson Disease Neurons

25 Nov 2015

Abstract excerpt

OBJECTIVE: To determine the extent of respiratory chain abnormalities and investigate the contribution of mtDNA to the loss of respiratory chain complexes (CI-IV) in the substantia nigra (SN) of idiopathic Parkinson disease (IPD) patients at the single-neuron level. METHODS: Multiple-label immunofluorescence was applied to postmortem sections of 10 IPD patients and 10 controls to quantify the abundance of CI-IV...

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PMID: 26605748
DOI: 10.1002/ana.24571

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