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Article

Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease

1 Oct 2019

Abstract excerpt

BACKGROUND: Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS: -associated Parkinson's disease (LRRK2-PD), using Selfie-digital PCR, a method that allows absolute quantification of mtDNA genomes and...

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PMID: 31631040
DOI: 10.1016/j.ebiom.2019.09.015

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