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Article

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.

Behavioural brain research - 15 Apr 2005

Grootendorst Jeannette, Bour Alexandra, Vogel Elise, Kelche Christian, Sullivan Patrick M, Dodart Jean-Cosme, Bales Kelly, Mathis Chantal

Abstract excerpt

Apolipoprotein E4 (apoE4), one of the three most common human apoE (h-apoE) isoforms, is a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. The biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent effect of h-apoE on cognitive performance was studied in gene-targeted mice, which show physiological...

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Identifiers

PMID: 15794991
DOI: 10.1016/j.bbr.2004.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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